What do you mean with enable/disable?

When talking about digital logic circuits, "disable" are often used when tristating an output, or when stopping a chip from listening to an input (like a counter ignoring the clock signal).

You can use macros for almost everything. The question is: why? Always, when you ask a question, supply enough information that a reader will know "why".

We can't tell you what is "a better way" unless you start by telling us "why" - what metric you are using that makes you want to use macros.

You can create named bit variables that sets a I/O pin high/low or that reads back the state of the pin.

Edit: Any sensible compiler should allow you to create named bit variables controlling I/O pins. If your specifically chosen C compiler allows this or not should be covered in the compiler manual. The manual you by now have spent some time looking through?